Everything about Mitoxantrone totally explained
Mitoxantrone is an Anthracenedione (not an anthracycline)
antineoplastic agent used in the treatment of certain types of cancer, mostly
metastatic breast cancer,
acute myeloid leukemia, and
non-Hodgkin's lymphoma.
Mitoxantrone is also used to treat
multiple sclerosis (MS), most notably the subset known as secondary progressive MS. Mitoxantrone won't cure multiple sclerosis, but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.
Mechanism of action
Mitoxantrone is a
type II topoisomerase inhibitor; it disrupts
DNA synthesis and
DNA repair in both healthy cells and cancer cells.
Side effects
As other drugs in its class, mitoxantrone may cause several
adverse reactions of varying severity, such as
nausea,
vomiting,
hair loss, heart damage, and
immunosuppression. Some side effects may have delayed onset.
Cardiomyopathy is a particularly concerning effect as it's irreversible; regular monitoring with
echocardiograms or
MUGA scans is recommended for people taking mitoxantrone.
The medication carries a total lifetime dose based on body surface area.
[Further Information]
Get more info on 'Mitoxantrone'.
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